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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6409 | ALK kinase inhibitor-1 | SAR348830 | Others |
SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase. | |||
T8152 | 6-Demethoxytangeretin | MAPK , ALK | |
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. | |||
T11254 | F-1 | ROS , ALK , ROS Kinase | |
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathwa... | |||
T3079 | GSK1838705A | IGF-1R , JNK , S6 Kinase , ALK | |
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases. | |||
T1962 | ASP3026 | ASP 3026 | Apoptosis , ALK |
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS. | |||
T15612 | JH-VIII-157-02 | Microtubule Associated , ALK | |
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L... | |||
T2612 | CEP-28122 | ALK | |
CEP-28122 is a highly potent and selective orally active ALK inhibitor. | |||
T16153 | MS4078 | ALK , Ligand for E3 Ligase | |
MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK. | |||
T4257 | Belizatinib | TSR-011 | Trk receptor , ALK |
Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC. | |||
T3621 | Brigatinib | AP-26113 | EGFR , FLT , ROS , IGF-1R , ALK |
Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor. | |||
T4015 | HG-14-10-04 | ALK | |
HG-14-10-04 is a potent and specific ALK inhibitor. | |||
T4071 | Repotrectinib | TPX-0005,TPX 0005,TPX0005 | Trk receptor , ROS , Src , ALK , ROS Kinase |
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively. | |||
T1791 | Ceritinib | LDK378 | Serine Protease , IGF-1R , ALK |
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM). | |||
T13416 | ZX-29 | ALK | |
ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect. | |||
T1661 | Crizotinib | PF-02341066 | c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase |
Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor. | |||
T3059 | ALK-IN-1 | AP26113,Brigatinib,AP26113-analog | EGFR , IGF-1R , ALK |
ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2. | |||
T2655 | CEP-37440 | CEP37440 | FAK , ALK |
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK). | |||
T3041 | ALK inhibitor 2 | FAK , ALK | |
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase. | |||
T10285 | ALK inhibitor 1 | FAK , IGF-1R , ALK | |
ALK inhibitor 1 is a selective ALK kinase inhibitor. | |||
T2641 | KRCA-0008 | KRCA 0008,KRCA0008 | ACK , ALK |
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability. |